Flights from Madrid Airport to Santiago Metropolitan Region

Travellers and cabin class

Flight deals from Madrid Airport to Santiago Metropolitan Region

Looking for cheap tickets from Madrid Airport to Santiago Metropolitan Region, or a last-minute trip? Find the lowest prices on one-way and return tickets right here.

Flying from Madrid Airport to Santiago Metropolitan Region

Arm yourself with these facts on the fly.
Cheapest flight foundP44,605, Santiago
Cheapest month to flyFebruary
Average flight time13 hrs, 26 mins
Average flights per week504
Most popular airlineLATAM Airlines

Frequently asked questions

Yes - direct flights currently operate from Madrid Airport to Santiago Arturo Merino Benitez Airport in Santiago Metropolitan Region.
We looked at all of the upcoming return flights from Madrid Airport to Santiago Metropolitan Region we could find over the next 12 months. It looks like P44,605 is the best price. This is good, compared to the average Santiago Metropolitan Region ticket price of P62,534.
The cheapest month to fly from Madrid Airport to Santiago Metropolitan Region is currently February.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Madrid Airport to Santiago Metropolitan Region on Saturday, 7 February 2026.
If you're flying from Madrid, the cheapest city in Santiago Metropolitan Region to fly into is Santiago. The cheapest airport serving Santiago at the moment is Santiago Arturo Merino Benitez.
The average flight time between Madrid Airport and Santiago Metropolitan Region is 13 hours and 26 minutes.