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Cheap flights from Mexico City to Panama City

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Compare Mexico City to Panama City flight deals

Find the cheapest month or even day of the year to fly to Panama City

Book the best Panama City fare with no extra fees

Flight deals from Mexico City to Panama City

Looking for a cheap last-minute deal or the best return flight from Mexico City to Panama City? Find the lowest prices on one-way and return tickets right here.
Panama City.P18,490 per passenger.Departing Sat, 29 Mar, returning Fri, 4 Apr.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Sat, 29 Mar, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 4 Apr, arriving in Mexico City Juarez International.Price includes taxes and charges.From P18,490, select.
Panama City.P18,490 per passenger.Departing Wed, 11 Jun, returning Wed, 18 Jun.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Wed, 11 Jun, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Wed, 18 Jun, arriving in Mexico City Juarez International.Price includes taxes and charges.From P18,490, select.
Panama City.P18,494 per passenger.Departing Sat, 8 Mar, returning Mon, 10 Mar.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Sat, 8 Mar, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 10 Mar, arriving in Mexico City Juarez International.Price includes taxes and charges.From P18,494, select.
Panama City.P18,494 per passenger.Departing Thu, 1 May, returning Fri, 9 May.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Thu, 1 May, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 9 May, arriving in Mexico City Juarez International.Price includes taxes and charges.From P18,494, select.
Panama City.P18,494 per passenger.Departing Thu, 24 Apr, returning Thu, 1 May.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Thu, 24 Apr, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Thu, 1 May, arriving in Mexico City Juarez International.Price includes taxes and charges.From P18,494, select.
Panama City.P18,608 per passenger.Departing Mon, 31 Mar, returning Fri, 6 Jun.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Mon, 31 Mar, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 6 Jun, arriving in Mexico City Juarez International.Price includes taxes and charges.From P18,608, select.
Panama City.P18,645 per passenger.Departing Wed, 23 Apr, returning Fri, 25 Apr.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Wed, 23 Apr, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 25 Apr, arriving in Mexico City Juarez International.Price includes taxes and charges.From P18,645, select.
Panama City.P19,677 per passenger.Departing Mon, 26 May, returning Mon, 2 Jun.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Mexico City Juarez International on Mon, 26 May, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 2 Jun, arriving in Mexico City Juarez International.Price includes taxes and charges.From P19,677, select.

Find the cheapest month to fly from Mexico City to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Mexico City to Panama City flights are currently cheapest in June.
Feb
Find prices
Mar
from P18,494
Apr
from P18,645
May
from P18,494
Jun
from P18,490
Jul
from P24,316
Aug
from P24,316
Sep
from P23,898
Oct
from P23,938
Nov
from P23,898
Dec
from P27,907
Jan
from P35,858

Direct flights from Mexico City to Panama City

Alternative Mexico City to Panama City routes

Looking for the cheapest, fastest or easiest route from Mexico City to Panama City? You could fly into the following airports instead.

Mexico City to Panama City: Flight information

The things to know before you go.
Cheapest flight foundP18,490
Cheapest month to flyMarch
Average flight time3 hrs, 40 mins
Most popular airlineCopa
Average flights per week78

Finding cheap flights from Mexico City to Panama City: Frequently asked questions

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.
The best price we found for a return flight from Mexico City to Panama City is P18,490. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
3 hours and 39 minutes is the average flight time from Mexico City to Panama City.
Copa, Emirates and MasAir fly direct from Mexico City to Panama City.
As of February 2025, there are 78 flights per week flying from Mexico City to Panama City.
The cheapest month to fly from Mexico City to Panama City is usually February 2025.
If you're flying from Mexico City, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the centre of Panama City. We've found flights into this airport from P18,490.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Mexico City to Panama City on Saturday, 29 March 2025.
Yes – the average flight time is 3 hours and 39 minutes.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.
In February, the average temperature is usually around 27°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.
The cheapest airline that flies to Panama City is Avianca. And the cheapest airline that flies to Balboa Airport is Copa.

Flying from Mexico City to Panama City: what you need to know

  • Mexico City has two main airports where you can start your adventure. Explore your options for booking a flight from Mexico City to Panama City leaving from Benito Juarez International Airport (MEX) or Santa Lucia Air Force Base (NLU).

  • When working out where to arrive in Panama City, Tocumen International Airport (PTY) and Panama Pacifico Airport (BLB) are the major hubs.

  • A direct flight from Mexico City to Panama City takes on average 3 hours 46 minutes. The timezone in Panama City is UTC-5, meaning it's 1 hour ahead of Mexico City.

  • Benito Juarez International Airport (MEX) to Tocumen International Airport (PTY) is the most popular route between these two cities. There are 39 flights a week to pick from. If you have things to do before leaving, the last flight from Mexico City to Panama City is with Copa Airlines at 15:45. Go for the first MEX to PTY departure with Copa Airlines at 01:20 to maximise your time in Panama City.

  • Leave plenty of time to make your flight from Mexico City to Panama City. As a general rule, arrive at least two hours before international departures and an hour ahead for domestic flights.

  • During popular months such as July, it's best to get to the airport earlier than usual. Plan to arrive two hours before domestic departures and four hours ahead of international flights whenever you're flying during peak periods in general.

  • If you have a passport from Mexico and plan to travel to Panama for tourism purposes, you won't need a visa. However, visa and entry requirements may vary based on your reason for visiting and are subject to change. For the most up-to-date information, check with your destination's nearest embassy or consulate before reserving a cheap flight from Mexico City to Panama City.

Flying from Mexico City

Benito Juarez International Airport (MEX)

  • You can reserve a direct flight from Mexico City to Panama City leaving from Benito Juarez International Airport (MEX). Begin your journey at MEX and end it at Tocumen International Airport (PTY).

  • You'll find a direct flight from Mexico City to Panama City with Copa Airlines. This top carrier offers services from MEX.

  • We make it a piece of cake to plan a flight from Mexico City to Panama City that includes a stopover. To see all the options leaving from Benito Juarez International Airport, uncheck 'Direct flights only.' Next, choose a flight offering a stop long enough to explore your chosen city. Major stopovers include:

    • Miguel Hidalgo y Costilla International Airport (GDL)

    • Juan Santamaria International Airport (SJO)

    • Cancun International Airport (CUN)

  • MEX is about 8 kilometres from central Mexico City. If you're ride-sharing, driving or catching a cab from the centre, it'll take you 24 minutes or so to get there, depending on traffic. If you're using public transport, expect the travel time to be approximately 57 minutes.

  • Catching an early flight from Mexico City to Panama City? Avoid the stress of rushing to the terminal (and catch some extra z's) by picking one of these hotels near Benito Juarez International Airport:

Santa Lucia Air Force Base Airport (NLU)

  • You can catch a nonstop flight from Mexico City to Panama City leaving from Santa Lucia Air Force Base Airport (NLU). Kick off your travels at NLU and in no time you'll be at Tocumen International Airport (PTY).

  • You can board a direct flight from Mexico City to Panama City with Copa Airlines. This is one of the main airlines operating this route out of NLU.

  • Get the most out of your holiday with a stopover on your flight from Mexico City to Panama City. Visit family or friends or tick a new city off your bucket list. Whatever you want to do, check out these stops between Benito Juarez International Airport and Panama City:

    • Miguel Hidalgo y Costilla International Airport (GDL)

    • Juan Santamaria International Airport (SJO)

    • Cancun International Airport (CUN)

  • You can arrive at NLU from the centre of Mexico City in about 55 minutes by car (depending on traffic). The journey by public transport will take roughly 1 hour and 46 minutes to travel the 40 kilometres or so.

  • Kick back before your flight from Mexico City to Panama City by spending the night near Santa Lucia Air Force Base Airport. Villa Granada is one option where you can roll out of bed and arrive at the airport with time to spare.

Arriving in Panama City

Tocumen International Airport (PTY)

Marcos A. Gelabert International Airport (PAC)

How to find the cheapest flights from Mexico City to Panama City

  • Right now, P10,530 is the lowest price we've seen for a one-way ticket from Mexico City to Panama City. The cheapest price for a return flight is P18,490. Remember fares can change due to availability at the time of booking.

  • Book 2 months before your departure date. After crunching the numbers on our calendar, this is how far you'll want to book ahead to secure cheap tickets from Mexico City to Panama City.

  • October is the cheapest month for tickets from Mexico City to Panama City. If you're looking to travel during a different time of year, the 'Whole month' tool will show you the lowest prices across every month.

  • Locking in a cheap ticket from Mexico City to Panama City couldn't be easier with Price Alerts. All you need to do is set up one of these automatic alerts and we'll get in touch when the price has fallen.

  • Tailor your flights using filters. Pick your ideal departure and arrival times, total journey duration and airlines. You can also sort your results by 'Best,' 'Cheapest' or 'Fastest' flights from Mexico City to Panama City.

Best time to go to Panama City

  • June is the busiest month for flights from Mexico City to Panama City. To steer clear of the crowds, visit Panama City in February.

  • When booking your flight from Mexico City to Panama City, think about the type of weather you enjoy. March is the warmest month in Panama City, with the temperature ranging from 21ºC to 32ºC.

  • Look for cheap tickets from Mexico City to Panama City in February if you like travelling in cooler conditions. Temperatures are at their lowest then, ranging between 22ºC and 31ºC on average.

More about Panama City

  • Start your Panama City trip off on the right foot by choosing the ideal place to stay. After booking your flight from Mexico City to Panama City, browse our range of hotels including:

  • There are so many things to do and see in this city it can be difficult to know where to start. Panama Canal Museum, Casco Viejo and Cinta Costera are popular attractions which should feature on every Panama City itinerary.

Complete your Panama City trip with a car rental

  • Finding you a cheap flight from Mexico City to Panama City isn't our only party trick. Check out our car rentals in Panama City and have more freedom to explore. We search for deals from trusted car rental companies and put them all in one place. Instantly compare rates and then book with no fees.

More travel options

Panama car hireBest car hire in Panama City
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Plan the rest of your trip from Mexico City to Panama City

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.